Peng/Hu/Wu/Li/Yang: Endothelial Dysfunction and Ventricular Remodeling in CKD

Background/Aims: To investigate the role of endothelial dysfunction on left ventricular remodeling in patients with chronic kidney disease and to evaluate the correlation between endothelial dysfunction and left ventricular remodeling. Methods: Seventy-three patients with chronic kidney disease as study-group and thirty healthy volunteers as control-group were enrolled in the present study. All patients in both groups had echocardiography examination. The concentration of endothelin-1, nitric oxide, and inducible nitric oxide synthase of serum of all patients and healthy volunteers was measured. The incidence of cardiac structural abnormalities in patients with chronic kidney disease, and the relationship between endothelial dysfunction and cardiac structural abnormalities were analyzed. Results: The incidence of left ventricular hypertrophy, left ventricular concentric remodeling, and left ventricular systolic dysfunction was 65%, 8.33%, and 16.67%, respectively. The level of endothelin-1 and nitric oxide increased in study-group, and the concentration of inducible nitric oxide synthase decreased. There was significant positively relationship between plasma endothelin-1 and left ventricular mass index, interventricular septal thickness, left ventricular diastolic diameter. There was negatively relationship between the level of serum nitric oxide and the maximum flow velocity at the mitral in left ventricular diastolic stage. There was not any correlation between inducible nitric oxide synthase with left ventricular remodeling. Conclusions: The results showed that there was a higher incidence of left ventricular hypertrophy in patients with chronic kidney disease. Endothelin-1 and nitric oxide played an important role on the development of left ventricular hypertrophy. Tao Peng and Xiangdong Yang contributed equally and thus sharing corresponding authorship. Tao Peng & Xiangdong Yang Department of Nephrology, Shandong University Qilu Hospital, 107 Wenhua Xi Road, Jinan, Shandong Province, 250012 (P. R. China), Tel. +86-531-8216-9316 E-mail: [email protected] D ow nl oa de d by : 54 .1 91 .4 0. 80 9 /1 7/ 20 17 3 :2 9: 19 A M Kidney Blood Press Res 2014;39:420-426 DOI: 10.1159/000368455 Published online: November 12, 2014 © 2014 S. Karger AG, Basel www.karger.com/kbr 421 Peng/Hu/Wu/Li/Yang: Endothelial Dysfunction and Ventricular Remodeling in CKD